{"id":3997,"date":"2026-10-22T00:30:02","date_gmt":"2026-10-21T22:30:02","guid":{"rendered":"https:\/\/medicontrol.it\/comment-redefining-curative-treatment-for-early-stage-mismatch-repair-deficient-colon-cancer\/"},"modified":"2026-10-22T00:30:02","modified_gmt":"2026-10-21T22:30:02","slug":"comment-redefining-curative-treatment-for-early-stage-mismatch-repair-deficient-colon-cancer","status":"publish","type":"post","link":"https:\/\/medicontrol.it\/en\/comment-redefining-curative-treatment-for-early-stage-mismatch-repair-deficient-colon-cancer\/","title":{"rendered":"[Comment] Redefining curative treatment for early-stage mismatch repair-deficient colon cancer"},"content":{"rendered":"<p>For decades, the standard of care for patients with resected stage II and III colon cancer has centred on surgery&hellip;\u00a0<a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(26)01612-0\/fulltext?rss=yes\" target=\"_blank\" class=\"feedzy-rss-link-icon\">Read More<\/a>\u200b\u00a0<\/p>","protected":false},"excerpt":{"rendered":"<p>For decades, the standard of care for patients with resected stage II and III colon cancer has centred on surgery with consideration of postoperative adjuvant systemic therapy to reduce risk of recurrence. Mismatch repair deficiency is seen in 10\u201315% of non-metastatic colon cancers and is predictive of response to immune checkpoint inhibition. The initial report of the single-arm, phase 2 NICHE-2 study of one dose of ipilimumab (1 mg per kg) and two doses of nivolumab (3 mg per kg) before surgery with clinical stage II and III colon cancer generated considerable interest after demonstrating a remarkable 98% pathologic response rate, including a pathologic complete response rate of 68%.<\/p>","protected":false},"author":2,"featured_media":130,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_templately_pack_id":"","_templately_imported_at":"","_templately_source":"","_templately_import_session_id":"","footnotes":""},"categories":[],"tags":[],"class_list":["post-3997","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"jetpack_featured_media_url":"https:\/\/medicontrol.it\/wp-content\/uploads\/2025\/09\/cropped-10.png","_links":{"self":[{"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/posts\/3997","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/comments?post=3997"}],"version-history":[{"count":0,"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/posts\/3997\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/media\/130"}],"wp:attachment":[{"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/media?parent=3997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/categories?post=3997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medicontrol.it\/en\/wp-json\/wp\/v2\/tags?post=3997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}